Team PROSPECT « Protein intake, nutrition security and cardiometabolic risk »
Aims and approaches
In the context of transitioning toward less animal protein and more plant protein consumption in our Western diets, the team studies the links between plant-based diets, nutrient adequacy, and long-term health. Historically, our work has included metabolic exploration studies following nutritional interventions, aimed at identifying mechanisms explaining the reduction in cardiometabolic risk associated with more plant-based dietary patterns. Currently, our activities primarily involve in silico diet simulation and optimization studies based on food consumption data. These studies aim to explore potential transitions toward healthier and more sustainable diets from a Public Health Nutrition perspective. Specifically, we investigate increasing plant protein in the diet to identify nutritional issues, dietary levers and the associated health benefits and risks. We also examine other features of dietary profiles (e.g., diversity, sovereignty) and integrate additional dimensions of sustainability such as environmental impacts and chemical risk. Recently, we have broadened our scope to address global food systems.
The team is a leading player in Public Health Nutrition in France. Over the past decade, our research has gained international recognition, particularly in the field of dietary protein plant-based transitions. The team plays a significant role in public nutrition expertise, maintaining strong collaborations with national institutions such as ANSES. Educational activities are also substantial, with three team members affiliated with AgroParisTech.
For the coming years (2025–2029), the team has outlined several specific objectives:
- Focusing on mineral nutrition, particularly the bioavailability of iron and zinc, which are critical in plant-based diets.
- Scaling up to a global food system perspective, advancing interdisciplinary approaches to understand how agricultural production and food processing characteristics influence population nutrition and health.
- Incorporating socioeconomic variables to analyze their influence on the relationships between protein consumption and health. This includes developing methods to characterize dietary transitions differentially across subpopulations.
- Methodologically enhancing long-term health impact models, by developing dynamic models and incorporating additional risks such as chemical exposure.
- Integrating broader sustainability dimensions, such as various environmental pressures, to develop a more holistic vision of dietary transitions.
Team members
► François Mariotti, team leader, Professor, AgroParisTech
Experience: Amino acid metabolism; vascular health.
Expertise: Nutritional requirements; nutritional status and risk; plant-based and vegetarian diets; dietary/nutritional recommendations.
Main project: Nutritional security and cardiometabolic risk assessment under scenarios of shifts in the nature (animal/plant) of protein intake.
Additional activity: Public nutrition expertise, particularly with ANSES (former Chairman of the Standing Committee on Nutrition, 2012–2022; current member of the Scientific Board, 2023–present).
Email: francois.mariotti@agroparistech.fr
LinkedIn : francois-mariotti
Twitter/X : F_Mariotti_FR
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► Hélène Fouillet, Researcher, INRAE
Experience: Modeling of metabolic and nutritional systems using isotopic and omics data analysis; modeling and optimization of dietary patterns through food consumption data analysis.
Expertise: Nutritional and pathophysiological modulations of protein metabolism; nutritional issues and dietary levers for protein plant-based transitions.
Main project: Multi-criteria optimization of dietary patterns across various dimensions of sustainability.
Additional activity: Member of the Scientific Council of the AlimH Department at INRAE.
Email: helene.fouillet@agroparistech.fr
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► Jean-François Huneau, Professor, AgroParisTech
Experience: Intestinal physiology and nutrient bioavailability; isotopic signatures of metabolic orientations.
Expertise: Nutritional requirements; amino acid metabolism.
Main project: Links between dietary plant-based transitions and nutritional quality among children and adolescents.
Additional activities: Public health nutrition expert, member of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) Specialized Nutrition Expert Committee (2012–2022), Head of the Human Nutrition Specialization (Master's level) at AgroParisTech (2010–present), Director of the Department of Biology and Human Nutrition, Life and Health Sciences Division, AgroParisTech (2018–2022).
Email: jean-francois.huneau@agroparistech.fr
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►Jeanne Neuffer-Frontout, Associate Professor, AgroParisTech
Experience: Public health; nutritional epidemiology; prevention of pathological brain aging; precision prevention.
Expertise: Modeling environment-health relationships; analysis of consumption and omics data; gene-environment interactions.
Main project: Nutritional and health determinants of sustainable dietary transitions—plant-based diets, social inequalities, and successful aging.
Email: jeanne.neuffer@agroparistech.fr
LinkedIn
►Elie Perraud, Researcher, INRAE
Experience: Assessment of dietary trajectories; analysis of consumption data.
Expertise: Modeling of food systems and dietary patterns; analysis of environmental pressures; benefit-risk assessments.
Main projects: Food systems and health; food substitution; fortification strategies.
Additional activity: Member of the Managing Board, PCI Nutrition.
Email: elperraud@inrae.fr
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► Juhui Wang, Research Ingeneer, INRAE
Role: Research engineer in applied mathematics and computer science.
Scientific interest: Development of mathematical tools and models to understand the relationship between dietary patterns, nutritional intake, and metabolic diseases.
Expertise:
As a mathematical engineer: Focus on Markovian modeling, sensitivity analysis, and Machine Learning.
As a computer scientist: Expertise in computer engineering, stochastic simulation of dynamic process propagation on complex networks, and High-Performance Computing (HPC).
►PhD students
► Anaëlle Bolo (10/2022-)
Analysis of the relationships between dietary diversity and the nutritional quality of dietary patterns.
Email: anaelle.bolo@agroparistech.fr
LinkedIn
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► Marianne Cerf (10/2023-)
A prospective analysis of the tensions between improved food self-sufficiency and a healthier, more sustainable food system.
Email: marianne.cerf1@agroparistech.fr
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► Sarah Chabert (01/2025-)
Influence of food grouping on the identification of healthier and more sustainable dietary patterns through multi-criteria optimization.
Co-supervised by ANSES.
► Pauline Mombert (01/2022-)
Multi-criteria assessment of the health benefit/risk of plant-forward diets.
Co-supervised by SECALIM.
Email: pauline.mombert@agroparistech.fr
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►Anciens membres de l'équipe
► Dominique Hermier, Research Director, INRAE
Experience: Identification of early dysregulations induced by Western-type consumption patterns in preclinical models, related to the lipidic environment of diets.
Expertise: Conducting preclinical protocols (rodents) to characterize cardiometabolic risk markers at the phenotypic, metabolic, and molecular levels.
Main project: Systemic pathophysiological consequences of early intestinal function alterations in response to a Western diet, and the effects of dietary transitions on the extent of these alterations.
Additional activity: Member of the Board of Directors and the Scientific Council of the French Nutrition Society.
► Annie Quignard-Boulangé, Emeritus Research Director, INSERM
Experience: Influence of dietary proteins on the control of adipose tissue development and inflammation in a nutritional obesity model. Mechanisms of metabolic syndrome prevention by ecdysteroids.
Project: Identification of plasma miRNAs as markers of the postprandial response in overweight individuals.
Additional activities: Member of the Scientific Council of the French Nutrition Society (SFN) and member of the national committee organizing the annual conference of the Journées Francophones de Nutrition (JFN).
► Eric Schoonejans, Chargé de recherches, INRAE
Experience: Health and environmental forecasting; risk assessment, management, and communication methodologies; regulatory surveillance of biotechnology; development of legal standards; molecular genetics.
Expertise: Sustainability and environmental, health, and socio-economic externalities of food systems; biosafety, GMOs, and biotechnology; international public law in environmental, health, and trade sectors.
Main project: Analysis of the foresight of sustainable food systems and their health, nutritional, environmental, and socio-economic impacts.
Additional activities: Member of the Foresight Working Group of the R31 network at ANSES; development of national safety frameworks for PED (Publicly Engaged Development).
► Véronique Mathé, Research technician, INRAE
► Moufidath Adjibade, Postdoc (2018-2019)
Evaluation of the effectiveness of tailored food swaps within the same food category for reducing diabetes risk.
►Anciens doctorants récemment diplômés
► Gaia Lépine (12/2023)
Nutritional transitions towards more plant-based proteins and fewer animal proteins: Understanding the metabolic reorientations induced and identifying their biomarkers.
Co-supervised by UNH.
► Elie Perraud (11/2023)
Characterization of optimal trajectories of micro-dietary changes during the flexitarian dietary transition: A comparative analysis of nutritional transition modalities and their impact on sustainability.
►Laurianne Dimina (10/2023)
Valorization of plant-based proteins in high-quality blends for specific populations. Application to the development of a protein ingredient and the characterization of its effects on cardiometabolic health in older adults.
Co-supervised by UNH.
► Alison Dussiot (09/2022)
What prospective and nutritional modalities for a flexitarian dietary transition in France? Analysis of the nutritional and dietary levers and barriers to reducing meat consumption.
Co-supervised by EREN.
► Marion Salomé (10/2021).
Role of protein-rich foods from the oilseed and protein crop sector in rebalancing protein intake in the French population: Analysis, simulation, and optimization based on French consumption data.
► Trenton Dailey-Chwalibóg (03/2020).
Biomedical Investigations for the Optimization of Diagnosis and Monitoring of Severe Acute Malnutrition (SAM): Understanding the heterogeneity of SAM diagnosis through anthropometric criteria and proposing alternatives. Joint supervision with Gent University.
► Erwan de Gavelle (07/2019).
Modeling acceptable trajectories for rearranging protein source consumption to enhance nutritional adequacy and assess impacts on sustainability.
► Olivier Landry-Mantha (2018). A novel isotopomics approach to identify dysregulations in protein and amino acid metabolism during the development of metabolic syndrome.
► Clelia Bianchi (2017). Development and evaluation of a step-by-step personalized dietary counseling method aimed at improving the nutritional adequacy of diets for pregnant women in France.
Peer-reviewed scientific publications
► 2024
Bolo A, Verger E, Fouillet H, Mariotti F. Exploring multidimensional and within-food group diversity for diet quality and long-term health in high-income countries. Advances in Nutrition. 2024;15(9):100278. doi: 10.1016/j.advnut.2024.100278. https://hal.inrae.fr/hal-04692145.
Dimina L, Jolata, Leray V, Voute M, David J, Blavignac C, Farges M-C, Rossary A, Tsikas D, Rémond D, Pickering G, Mariotti F. Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial Impairments in Vascular Endothelial Function in Healthy Older Adults with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial. Journal of Nutrition. 2024;154(12):3664 - 80. doi: 10.1016/j.tjnut.2024.10.018. https://hal.science/hal-04819050.
Guy-Grand B, Coxam V, Mariotti F, Peyraud J-L, J.L., Wilfart A, Morio B. How can we cover our nutritional requirements with a sustainable diet? Focus on proteins and calcium - Summary of the online SFN workshop in partnership with Bel held on Wednesday 21st June 2023. Cahiers de Nutrition et de Diététique. 2024;59(2):76-81. doi: 10.1016/j.cnd.2024.01.001. https://hal.inrae.fr/hal-04495509.
Kesse-Guyot E, Berthy F, Berlivet J, Perraud E, Touvier M, Hercberg S, et al. Alignment between greenhouse gas emissions reduction and adherence the EAT-Lancet diet: A modeling study based on the NutriNet-Santé cohort. Science of the Total Environment. 2024;951(10440):175470. doi: 10.1016/j.scitotenv.2024.175470. https://hal.science/hal-04676885.
Lépine G, Mariotti F, Tremblay-Franco M, Courrent M, Verny M-A, David J, et al. Increasing plant protein in the diet induces changes in the plasma metabolome that may be beneficial for metabolic health. A randomized crossover study in males. Clinical Nutrition. 2024;43(12):146 - 57. doi: 10.1016/j.clnu.2024.10.009. https://hal.inrae.fr/hal-04769512.
Levasseur P, Mariotti F, Denis I, Davidenko O. Potential unexpected effects of meat reduction in diet: Could educational attainment influence meat substitution strategies? Agricultural and Food Economics. 2024;12(1):4. doi: 10.1186/s40100-024-00298-7. https://hal.science/hal-04426863.
Mariotti F. Plant and animal proteins: seeing both the trees and the forest. The American Journal of Clinical Nutrition. 2024;120(6):1309-10. doi: https://doi.org/10.1016/j.ajcnut.2024.10.005. https://hal.science/hal-04819122.
Mariotti F, Gardner C, Fouillet H, Huneau J-F. Regarding: the impacts of partial replacement of red and processed meat with legumes or cereals on protein and amino acid intakes: a modelling study in the Finnish adult population. Annals of Medicine. 2024;56(1). doi: 10.1080/07853890.2024.2341757. https://hal.science/hal-04576013.
Mariotti F. What do we know about dietary diversity? The nutrition & health viewpoint. Innovations Agronomiques. 2024;92:1-11. doi: 10.17180/ciag-2024-vol92-art01. https://hal.inrae.fr/hal-04573142.
Perraud E, Wang J, Fouillet H, Mariotti F. In healthy pathways of dietary changes, a very rapid reduction of red meat is possible, but specific diet changes are required for full reduction – a graph-based analysis. Journal of Nutrition. 2024;154(8):2599-607. doi: 10.1016/j.tjnut.2024.06.008. https://hal.science/hal-04626436.
Toujgani H, Berlivet J, Berthy F, Allès B, Brunin J, Fouillet H, et al. Dietary Pattern Trajectories in French Adults of the NutriNet-Santé Cohort Over Time (2014-2022): Role of Socioeconomic Factors. British Journal of Nutrition. 2024:1-29. doi: 10.1017/s0007114524002514. https://hal.science/hal-04752121.
► 2023
Berthy F, Brunin J, Allès B, Reuzé A, Hercberg S, Lairon D, Pointereau P, Mariotti F, Baudry J, Kesse-Guyot E. Higher adherence to the EAT-Lancet reference diet is associated with higher nutrient adequacy in the NutriNet-Santé cohort: a cross-sectional study. The American Journal of Clinical Nutrition. 2023;117(6):1174-85. doi: 10.1016/j.ajcnut.2023.03.029. https://hal.science/hal-04079271.
Dimina L, Tremblay-Franco M, Deveaux A, Tardivel C, Fouillet H, Polakof S, Martin J-C, Mariotti F. Plasma Metabolome Analysis Suggests That L-Arginine Supplementation Affects Microbial Activity Resulting in a Decrease in Trimethylamine N-oxide—A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors. Current Developments in Nutrition. 2023;7(12):102038. doi: 10.1016/j.cdnut.2023.102038. https://hal.science/hal-04330272.
Dimina L, Landais J, Mathe V, Jarzaguet M, Le Bourgot C, Hermier D, Mariotti F, Remond D, Mosoni L. Plant Protein Can Be as Efficient as Milk Protein to Maintain Fat Free Mass in Old Rats, Even When Fat and Sugar Intakes Are High. Journal of Nutrition. 2023;153(9):2631-41. doi: 10.1016/j.tjnut.2023.01.025. https://hal.inrae.fr/hal-04197061.
Dussiot A, Fouillet H, Perraud E, Salomé M, Huneau J, Mariotti F, Kesse-Guyot E. How to best reshape diets to be healthier with lower or no ruminant meat, and implications for environmental pressures. Journal of Cleaner Production. 2023;414:pp. 137600. doi: 10.1016/j.jclepro.2023.137600. https://hal.science/hal-04192398.
Elango R, Mariotti F. Editorial: Beyond traditional roles for amino acids. Current Opinion in Clinical Nutrition and Metabolic Care. 2023;26(2):pp. 186-8. doi: 10.1097/mco.0000000000000905. https://hal.science/hal-04319575.
Fouillet H, Dussiot A, Perraud E, Wang J, Huneau J-F, Kesse-Guyot E, Mariotti F. Plant to animal protein ratio in the diet: nutrient adequacy, long-term health and environmental pressure. Frontiers in Nutrition. 2023;10:pp. 1178121. doi: 10.3389/fnut.2023.1178121. https://cnam.hal.science/hal-04187135.
Kesse-Guyot E, Allès B, Brunin J, Fouillet H, Dussiot A, Berthy F, et al. Environmental impacts along the value chain from the consumption of ultra-processed foods. Nature Sustainability. 2023;6:192-202. doi: 10.1038/s41893-022-01013-4. https://cnam.hal.science/hal-04080613.
Kesse-Guyot E, Allès B, Brunin J, Langevin B, Fouillet H, Dussiot A, et al. Environmental pressures and pesticide exposure associated with an increase in the share of plant-based foods in the diet. Scientific Reports. 2023;13(1):19317. doi: 10.1038/s41598-023-46032-z. https://hal.inrae.fr/hal-04320664.
Kesse-Guyot E, Pointereau P, Brunin J, Perraud E, Toujgani H, Berthy F, et al. Trade-offs between blue water use and greenhouse gas emissions related to food systems : An optimization study for French adults. Sustainable Production and Consumption. 2023;42:33-43. doi: 10.1016/j.spc.2023.09.008. https://hal.inrae.fr/hal-04238352.
Lépine G, Huneau J-F, Remond D, Mathé V, David J, Hermier D, et al. Compared with Milk Protein, a Wheat and Pea Protein Blend Reduces High-Fat, High-Sucrose Induced Metabolic Dysregulations while Similarly Supporting Tissue Protein Anabolism in Rats. Journal of Nutrition. 2023;153(3):645-56. doi: 10.1016/j.tjnut.2022.12.029. https://hal.science/hal-03940315.
Mariotti F, Huneau J-F, Fouillet H. No Nutritional Lessons Can Be Learned from a Misspecified and Overrestricted Model with No Sensitivity Analysis. Journal of Nutrition. 2023;153(3):pp. 911-2. doi: 10.1016/j.tjnut.2022.12.021. https://hal.science/hal-04005783.
Mariotti F. Nutritional and health benefits and risks of plant-based substitute foods. Proceedings of the Nutrition Society. 2023:pp. 1-32. doi: 10.1017/s0029665123004767. https://hal.science/hal-04261367.
Messina M, Duncan A, Glenn A, Mariotti F. Perspective: Plant-Based Meat Alternatives Can Help Facilitate and Maintain a Lower Animal to Plant Protein Intake Ratio. Advances in Nutrition. 2023;14(3):pp. 392-405. doi: 10.1016/j.advnut.2023.03.003. https://hal.science/hal-04319571.
Perraud E, Wang J, Dussiot A, Fouillet H, Mariotti F. Identifying the most Efficient Detailed Trajectories toward Healthy Diets — A Graph-Based Analysis. Journal of Nutrition. 2023;153(9):pp. 2744-52. doi: 10.1016/j.tjnut.2023.07.007. https://hal.inrae.fr/hal-04186238.
Perraud E, Wang J, Salomé M, Mariotti F, Kesse-Guyot E. Dietary protein consumption profiles show contrasting impacts on environmental and health indicators. Science of the Total Environment. 2023;856(1):159052. doi: 10.1016/j.scitotenv.2022.159052. https://hal.science/hal-03823126.
Poissant R, Mariotti F, Zalko D, Membré J-M. Ranking food products based on estimating and combining their microbiological, chemical and nutritional risks: Method and application to Ready-To-Eat dishes sold in France. Food Research International. 2023;169:112939. doi: 10.1016/j.foodres.2023.112939. https://hal.inrae.fr/hal-04104363.
Salomé M, Mariotti F, Dussiot A, Kesse-Guyot E, Huneau J-F, Fouillet H. Plant-based meat substitutes are useful for healthier dietary patterns when adequately formulated – an optimization study in French adults (INCA3). European Journal of Nutrition. 2023;62(4):1891-901. doi: 10.1007/s00394-023-03117-9. https://cnam.hal.science/hal-04067531.
Toujgani H, Brunin J, Perraud E, Allès B, Touvier M, Lairon D, Mariotti F, Pointereau P, Baudry J, Kesse-Guyot E. The nature of protein intake as a discriminating factor of diet sustainability: a multi-criteria approach. Scientific Reports. 2023;13(1):17850. doi: 10.1038/s41598-023-44872-3. https://hal.science/hal-04350853.
► 2022
Baskal S, Dimina L, Tsikas SA, Mosoni L, Remond D, Mariotti F, Tsikas D. Lysine and homoarginine are closely interrelated metabolites in the rat. Amino Acids. 2022;54:pages 967–76. doi: 10.1007/s00726-022-03158-0. https://uca.hal.science/hal-03655502.
Bianchi C, Mariotti F, Reulet E, Le Goff G, Lluch A, Verger E, Huneau J-F, Gurviez P. Perceptions of tailored dietary advice to improve the nutrient adequacy of the diet in french pregnant women. Nutrients. 2022;14(1):85. doi: 10.3390/nu14010085. https://hal.inrae.fr/hal-03516841.
Dimina L, Huneau J-F, Remond D, Mariotti F. Combining Plant Proteins to Achieve Amino Acid Profiles Adapted to Various Nutritional Objectives—An Exploratory Analysis Using Linear Programming. Frontiers in Nutrition. 2022;8:809685. doi: 10.3389/fnut.2021.809685. https://hal.inrae.fr/hal-03553998.
Dussiot A, Fouillet H, Wang J, Salomé M, Huneau J-F, Kesse-Guyot E, Mariotti F. Modeled healthy eating patterns are largely constrained by currently estimated requirements for bioavailable iron and zinc – a diet optimization study in French Adults. The American Journal of Clinical Nutrition. 2022;115(3):p. 958-69. doi: 10.1093/ajcn/nqab373. https://hal.science/hal-03442190.
Dussiot A, Fouillet H, Perraud E, Salomé M, Huneau J-F, Kesse-Guyot E, Mariotti F. Nutritional issues and dietary levers during gradual meat reduction - a sequential diet optimization study to achieve progressively healthier diets. Clinical Nutrition. 2022;41(12):pp. 2597-606. doi: 10.1016/j.clnu.2022.09.017. https://hal.science/hal-03823181.
Kesse-Guyot E, Allès B, Brunin J, Fouillet H, Dussiot A, Mariotti F, et al.Nutritionally adequate and environmentally respectful diets are possible for different diet groups: an optimized study from the NutriNet - Santé cohort. The American Journal of Clinical Nutrition. 2022;116(6):1621-33. doi: 10.1093/ajcn/nqac253. https://hal.inrae.fr/hal-03843320.
Lépine G, Tremblay-Franco M, Bouder S, Dimina L, Fouillet H, Mariotti F, Polakof S. Investigating the Postprandial Metabolome after Challenge Tests to Assess Metabolic Flexibility and Dysregulations Associated with Cardiometabolic Diseases. Nutrients. 2022;14(3). doi: 10.3390/nu14030472. https://hal.inrae.fr/hal-03601797.
Perraud E, Wang J, Salomé M, Huneau J-F, Lapidus N, Mariotti F. Plant and Animal Protein Intakes Largely Explain the Nutritional Quality and Health Value of Diets Higher in Plants: A Path Analysis in French Adults. Frontiers in Nutrition. 2022;9:924526. doi: 10.3389/fnut.2022.924526. https://hal.science/hal-03707121.
Salomé M, Mariotti F, Nicaud M-C, Dussiot A, Kesse-Guyot E, Maillard M-N, Huneau J-F, Fouillet H. The potential effects of meat substitution on diet quality could be high if meat substitutes are optimized for nutritional composition - a modeling study in French adults (INCA3). European Journal of Nutrition. 2022;61(4):1991-2002. doi: 10.1007/s00394-021-02781-z. https://hal.inrae.fr/hal-03483092.
Savary-Auzeloux I, Jarzaguet M, Migné C, Mariotti F, Kemeny J-L, Mathé V, et al. Anti-inflammatory Streptococcus thermophilus CNRZ160 limits sarcopenia induced by low-grade inflammation in older adult rats. Frontiers in Nutrition. 2022;9:986542. doi: 10.3389/fnut.2022.986542. https://hal.inrae.fr/hal-04013541.
Tsikas D, Maassen N, Thorns A, Finkel A, Lützow M, Röhrig M, Aleksandra, et al. Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise. International Journal of Molecular Sciences. 2022;23. doi: 10.3390/ijms231810649. https://hal.science/hal-04319585.
► 2021
Adjibade M, Mariotti F, Leroy P, Souchon I, Saint-Eve A, Fagherazzi G, Soler L-G, Huneau J-F. Impact of intra-category food substitutions on the risk of type 2 diabetes: a modelling study on the pizza category. British Journal of Nutrition. 2021. doi: 10.1017/s0007114521002130. https://hal.science/hal-03355131.
Dailey-Chwalibóg T, Freemark M, Muehlbauer M, Roberfroid D, Kemokai I, Mostak MR, et al. Clinical and Biochemical Markers of Risk in Uncomplicated Severe Acute Malnutrition. Pediatrics. 2021;147(6). doi: 10.1542/peds.2020-027003. https://agroparistech.hal.science/hal-03481218.
Kesse-Guyot E, Rebouillat P, Brunin J, Langevin B, Allès B, Touvier M, et al. Environmental and nutritional analysis of the EAT-Lancet diet at the individual level: insights from the NutriNet-Santé study. Journal of Cleaner Production. 2021;296:126555. doi: 10.1016/j.jclepro.2021.126555. https://hal.inrae.fr/hal-03173808.
Kesse-Guyot E, Fouillet H, Baudry J, Dussot A, Langevin B, Allès B, et al. Halving food-related greenhouse gas emissions can be achieved by redistributing meat consumption: progressive optimization Results of the NutriNet-Santé cohort. Science of the Total Environment. 2021;789:147901. doi: 10.1016/j.scitotenv.2021.147901. https://hal.inrae.fr/hal-03238402.
Lépine G, Fouillet H, Rémond D, Huneau J-F, Mariotti F, Polakof S. A Scoping Review: Metabolomics Signatures Associated with Animal and Plant Protein Intake and Their Potential Relation with Cardiometabolic Risk. Advances in Nutrition. 2021;12(6):2112-31. doi: 10.1093/advances/nmab073. https://hal.science/hal-03291370.
Mariotti F, Havard S, Morise A, Nadaud P, Sirot V, Wetzler S, Margaritis I. Perspective: Modeling Healthy Eating Patterns for Food-Based Dietary Guidelines—Scientific Concepts, Methodological Processes, Limitations, and Lessons. Advances in Nutrition. 2021;12(3):590-9. doi: 10.1093/advances/nmaa176. https://anses.hal.science/anses-03191497.
Salomé M, Arrazat L, Wang J, Dufour A, Dubuisson C, Volatier J-L, J.L., Huneau J-F, Mariotti F. Contrary to ultra-processed foods, the consumption of unprocessed or minimally processed foods is associated with favorable patterns of protein intake, diet quality and lower cardiometabolic risk in French adults (INCA3). European Journal of Nutrition. 2021. doi: 10.1007/s00394-021-02576-2. https://hal.science/hal-03280956.
Salomé M, Huneau J-F, Le baron C, Kesse-Guyot E, Fouillet H, Mariotti F. Substituting Meat or Dairy Products with Plant-Based Substitutes Has Small and Heterogeneous Effects on Diet Quality and Nutrient Security: A Simulation Study in French Adults (INCA3). Journal of Nutrition. 2021;151(8):2435-45. doi: 10.1093/jn/nxab146. https://hal.science/hal-03317943.
Seconda L, Fouillet H, Huneau J-F, Pointereau P, Baudry J, Langevin B, et al. Conservative to disruptive diets for optimizing nutrition, environmental impacts and cost in French adults from the NutriNet-Santé cohort. Nature Food. 2021;2:174–82. doi: 10.1038/s43016-021-00227-7. https://hal.inrae.fr/hal-03173585.
Verger E, O, Le Port A, Borderon A, Bourbon G, Moursi M, Savy M, Mariotti F, Martin-Prével Y. Dietary Diversity Indicators and Their Associations with Dietary Adequacy and Health Outcomes : A Systematic Scoping Review. Advances in Nutrition. 2021;12(5):1659-72. doi: 10.1093/advances/nmab009. https://ird.hal.science/ird-03159901.
► 2020
Bianchi C, Mariotti F, Lluch A, A., Journet C, Stehr Y, Beaussier H, et al.Computer-based tailored dietary counseling improves the nutrient adequacy of the diet of French pregnant women: a randomized controlled trial. British Journal of Nutrition. 2020;123(2):220-31. doi: 10.1017/s0007114519002617. https://hal.science/hal-02366520.
Dailey-Chwalibóg T, Huneau J-F, Mathé V, Kolsteren P, Mariotti F, Mostak MR, et al. Weaning and stunting affect nitrogen and carbon stable isotope natural abundances in the hair of young children. Scientific Reports. 2020;10(1). doi: 10.1038/s41598-020-59402-8. https://agroparistech.hal.science/hal-02776973.
Kesse-Guyot E, Chaltiel D, Wang J, Pointereau P, Langevin B, Allès B, et al. Sustainability analysis of French dietary guidelines using multiple criteria. Nature Sustainability. 2020;3(5):377-85. doi: 10.1038/s41893-020-0495-8. https://hal.science/hal-02912151.
Lecorguillé M, Lioret S, de Lauzon-Guillain B, de Gavelle E, Forhan A, Mariotti F, Charles M-A, Heude B. Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry. Nutrients. 2020;12(3):838. doi: 10.3390/nu12030838. https://hal.inrae.fr/hal-02904865.
Lortal S, El Mecherfi K-E, Mariotti F, Eutamène H, Rul F, Champomier-Vergès M-C, Savary-Auzeloux I. Fermented foods & health benefits: A challenge for research. Cahiers de Nutrition et de Diététique. 2020;55(3):136-48. doi: 10.1016/j.cnd.2020.02.004. https://hal.science/hal-02936312.
Mantha O, Huneau J-F, Mathé V, Hermier D, D., Khodorova N, N., Mariotti F, Fouillet H. Differential changes to splanchnic and peripheral protein metabolism during the diet-induced development of metabolic syndrome in rats. AJP - Endocrinology and Metabolism. 2020;319:E175-E86. doi: 10.1152/ajpendo.00061.2020. https://agroparistech.hal.science/hal-02777057.
Mariotti F, Bianchi C, Huneau J-F. Invited commentary in response to: Risk of overestimating treatment effects and generalisability of computer-based tailored dietary counselling. British Journal of Nutrition. 2020;123(8):959-60. doi: 10.1017/s0007114520000355. https://hal.science/hal-02943583.
Mariotti F, Gardner C. Adéquation de l’apport en protéines et acides aminés dans les régimes végétariens. Cahiers de Nutrition et de Diététique. 2020;55(2):66-81. doi: 10.1016/j.cnd.2019.12.002. https://hal.science/hal-02943584.
Mariotti F. Arginine supplementation and cardiometabolic risk. Current Opinion in Clinical Nutrition and Metabolic Care. 2020;23(1):pp. 29-34. doi: 10.1097/mco.0000000000000612. https://hal.science/hal-02346025.
Salomé M, Kesse-Guyot E, Fouillet H, Touvier M, Hercberg S, Huneau J-F, Mariotti F. Development and evaluation of a new dietary index assessing nutrient security by aggregating probabilistic estimates of the risk of nutrient deficiency in two French adult populations. British Journal of Nutrition. 2020;126(8):1225-36. doi: 10.1017/s0007114520005115. https://hal.science/hal-03200910.
Tharrey M, Mariotti F, Mashchak A, Barbillon P, Delattre M, Huneau J-F, Fraser G. Patterns of amino acids intake are strongly associated with cardiovascular mortality, independently of the sources of protein. International Journal of Epidemiology. 2020;49(1):312 - 21. doi: 10.1093/ije/dyz194. https://hal.science/hal-02366516.
► 2019
Bollenbach A, Huneau J-F, Mariotti F, Tsikas D. Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men. Nutrients. 2019;11(7):1463. doi: 10.3390/nu11071463. https://agroparistech.hal.science/hal-02179293.
Cantalapiedra-Hijar G, Fouillet H, Chantelauze C, Khodorova N, N., Bahloul L, Ortigues Marty I. The isotopic nitrogen turnover rate as a proxy to evaluate in the long-term the protein turnover in growing ruminants. Journal of Agricultural Science. 2019;157(9-10):701-10. doi: 10.1017/s0021859620000118. https://hal.inrae.fr/hal-02565565.
de Gavelle E, Davidenko O, Fouillet H, Delarue J, Darcel N, Huneau J-F, Mariotti F. Self-declared attitudes and beliefs regarding protein sources are a good prediction of the degree of transition to a low-meat diet in France. Appetite. 2019;142:104345. doi: 10.1016/j.appet.2019.104345. https://agroparistech.hal.science/hal-02179307.
de Gavelle E, Leroy P, Perrimon M, Huneau J-F, Sirot V, Orset C, Fouillet H, Soler LG, Mariotti F. Modeled gradual changes in protein intake to increase nutrient adequacy lead to greater sustainability when systematically targeting an increase in the share of plant protein. Climatic Change. 2019;161:129–49. doi: 10.1007/s10584-019-02592-6. https://hal.science/hal-02483841.
de Gavelle E, Davidenko O, Fouillet H, Delarue J, Darcel N, N., Huneau J-F, Mariotti F. The Willingness to Modify Portion Sizes or Eat New Protein Foods Largely Depends on the Dietary Pattern of Protein Intake. Nutrients. 2019;11(7):1556. doi: 10.3390/nu11071556. https://hal.science/hal-02295001.
de Gavelle E, Huneau J-F, Fouillet H, Mariotti F. The Initial Dietary Pattern Should Be Considered when Changing Protein Food Portion Sizes to Increase Nutrient Adequacy in French Adults. Journal of Nutrition. 2019;149(3):488-96. doi: 10.1093/jn/nxy275. https://hal.science/hal-02006873.
Dimina L, Mariotti F. The Postprandial Appearance of Features of Cardiometabolic Risk: Acute Induction and Prevention by Nutrients and Other Dietary Substances. Nutrients. 2019;11(9):1963. doi: 10.3390/nu11091963. https://hal.science/hal-02294998.
Houngbe F, Tonguet-Papucci A, Nago E, Gauny J, Aït Aïssa M, Huneau J-F, Kolsteren P, Huybregts L. Effects of multiannual, seasonal unconditional cash transfers on food security and dietary diversity in rural Burkina Faso: the Moderate Acute Malnutrition Out (MAM’Out) cluster-randomized controlled trial. Public Health Nutrition. 2019;22(6):1-11. doi: 10.1017/s1368980018003452. https://hal.science/hal-02007684.
Huneau J-F, Mantha O, Hermier D, D., Mathe V, Galmiche G, Mariotti F, Fouillet H. Natural isotope abundances of carbon and nitrogen in tissue proteins and amino acids as biomarkers of the decreased carbohydrate oxidation and increased amino acid oxidation induced by caloric restriction under a maintained protein intake in obese rats. Nutrients. 2019;11(5):1087. doi: 10.3390/nu11051087. https://agroparistech.hal.science/hal-02179296.
Mariotti F. Animal and Plant Protein Sources and Cardiometabolic Health. Advances in Nutrition. 2019;10(Supplement_4):S351-S66. doi: 10.1093/advances/nmy110. https://hal.science/hal-02366513.
Mariotti F. Protéines animales et végétales : quels effets sur la santé cardio-métabolique ? Médecine des Maladies Métaboliques. 2019;13(3):245-51. doi: 10.1016/s1957-2557(19)30069-0. https://hal.science/hal-02295004.
Mariotti F, Gardner C, D. Dietary Protein and Amino Acids in Vegetarian Diets-A Review. Nutrients. 2019;11(11):2661. doi: 10.3390/nu11112661. https://hal.science/hal-02346001.
Salomé M, De gavelle E, Dufour A, Dubuisson C, C., Volatier J-L, Fouillet H, Huneau J-F, Mariotti F. Plant-Protein Diversity Is Critical to Ensuring the Nutritional Adequacy of Diets When Replacing Animal With Plant Protein: Observed and Modeled Diets of French Adults (INCA3). Journal of Nutrition. 2019;150(3):536–45. doi: 10.1093/jn/nxz252. https://hal.science/hal-02366514.
► 2018
Bianchi C, Huneau J-F, Barbillon P, Lluch A, Egnell M, Fouillet H, Verger E, Mariotti F. A clear trade-off exists between the theoretical efficiency and acceptability of dietary changes that improve nutrient adequacy during early pregnancy in French women: Combined data from simulated changes modeling and online assessment survey. PLoS ONE. 2018;13(4). doi: 10.1371/journal.pone.0194764. https://hal.science/hal-01766756.
de Gavelle E, Huneau J-F, Mariotti F. Patterns of Protein Food Intake Are Associated with Nutrient Adequacy in the General French Adult Population. Nutrients. 2018;10(2). doi: 10.3390/nu10020226. https://hal.science/hal-01761203.
Hermier D, D., Mariotti F. Importance of protein and amino acid metabolism in the prevention and management of the metabolic syndrome. Modulation by n-3 fatty acids. Cahiers de Nutrition et de Diététique. 2018;53(5):267-78. doi: 10.1016/j.cnd.2018.06.002. https://hal.science/hal-02006877.
Mantha O, Polakof S, Huneau J-F, Mariotti F, Poupin N, Zalko D, Fouillet H. Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet: evidence from natural isotope abundances of nitrogen and carbon in tissue proteins. British Journal of Nutrition. 2018;119(9):981-91. doi: 10.1017/s0007114518000326. https://hal.science/hal-01761202.
Pujos-Guillot E, Brandolini-Bunlon M, Fouillet H, Joly C, Martin J-F, Huneau J-F, Dardevet D, Mariotti F. Metabolomics Reveals that the Type of Protein in a High-Fat Meal Modulates Postprandial Mitochondrial Overload and Incomplete Substrate Oxidation in Healthy Overweight Men. Journal of Nutrition. 2018;148(6):876-84. doi: 10.1093/jn/nxy049. https://hal.science/hal-01827937.
Tappy L, Morio B, Azzout-Marniche D, Champ M, Gerber M, Houdart S, et al. French Recommendations for Sugar Intake in Adults: A Novel Approach Chosen by ANSES. Nutrients. 2018;10(8):16. doi: 10.3390/nu10080989. https://hal.science/hal-02003572.
Tharrey M, Mariotti F, Mashchak A, Barbillon P, M, Delattre M, Fraser GE. Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality: the Adventist Health Study-2 cohort. International Journal of Epidemiology. 2018;47(5):1603–12. doi: 10.1093/ije/dyy030. https://hal.science/hal-01766695.
Tsikas D, Hanff E, Bollenbach A, Kruger R, Pham VV, Chobanyan-Jürgens J, et al. Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings. Amino Acids. 2018;50(7):799–821. doi: 10.1007/s00726-018-2573-z. https://hal.science/hal-01789319.
► 2017
Cantalapiedra-Hijar G, Dewhurst R, Cheng L, Cabrita A, R. J., Fonseca A, Noziere P, Makowski D, Fouillet H, Ortigues Marty I. Nitrogen isotopic fractionation as a biomarker for nitrogen use efficiency in ruminants: a meta-analysis. Animal. 2017;12(9):1 - 11. doi: 10.1017/s1751731117003391. https://hal.science/hal-01777612.
de Gavelle E, Huneau J-F, Bianchi C, M, Verger E, O, Mariotti F. Protein Adequacy Is Primarily a Matter of Protein Quantity, Not Quality: Modeling an Increase in Plant:Animal Protein Ratio in French Adults. Nutrients. 2017;9(12):1333. doi: 10.3390/nu9121333. https://hal.science/hal-01661871.
Fardet A, Morise A, Kalonji E, Margaritis I, Mariotti F. Influence of phytosterol and phytostanol food supplementation on plasma liposoluble vitamins and provitamin A carotenoid levels in humans: An updated review of the evidence. Critical Reviews in Food Science and Nutrition. 2017;57(9):1906-21. doi: 10.1080/10408398.2015.1033611. https://hal.science/hal-01506623.
Hanff E, Kayacelebi AA, Mariotti F, Herrmann C, Obermann M, Das AM, Tsikas D. Analytical challenges in the assessment of NO synthesis from L-arginine in the MELAS syndrome. International Journal of Cardiology. 2017;234:141-2. doi: 10.1016/j.ijcard.2016.12.036. https://agroparistech.hal.science/hal-01576900.
Hermier D, Mathé V, Lan A, Santini C, Huneau J-F, Mariotti F. Postprandial low-grade inflammation does not specifically require TLR4 activation in the rat. Nutrition and Metabolism. 2017;14(1):1-7. doi: 10.1186/s12986-017-0220-4. https://agroparistech.hal.science/hal-01620748.
Mariotti F. Vegetarian diets and health: the voice of science needs to be heard. The Conversation France. 2017. https://hal.science/hal-01766750.
Mariotti F. Manger végétarien, bon pour la santé ? Ce que dit, et ce que ne dit pas la science. The Conversation France. 2017. https://hal.science/hal-01766749.
Tonguet-Papucci A, Houngbe F, Lompo P, Yameogo WME, Huneau J-F, Ait Aissa M, Kolsteren P. Beneficiaries’ perceptions and reported use of unconditional cash transfers intended to prevent acute malnutrition in children in poor rural communities in Burkina Faso: qualitative results from the MAM’Out randomized controlled trial. BMC Public Health. 2017;17(1):1-12. doi: 10.1186/s12889-017-4453-y. https://agroparistech.hal.science/hal-01572220.
Tonguet-Papucci A, Houngbe F, Huybregts L, Ait Aissa M, Altare C, Kolsteren P, Huneau J-F. Unconditional seasonal cash transfer increases intake of high-nutritional-value foods in young Burkinabe children: results of 24-hour dietary recall surveys within the MAM’Out randomized controlled trial. Journal of Nutrition. 2017;147(7):1426-36. doi: 10.3945/jn.116.244517. https://agroparistech.hal.science/hal-01572245.
► 2016
Bianchi CM, Huneau J-F, Le Goff G, Verger EO, Mariotti F, Gurviez P. Concerns, attitudes, beliefs and information seeking practices with respect to nutrition-related issues: a qualitative study in French pregnant women. BMC Pregnancy and Childbirth. 2016;16(e-306):np. doi: 10.1186/s12884-016-1078-6. https://agroparistech.hal.science/hal-01488444.
Bianchi CM, Egnell M, Huneau J-F, Mariotti F. Plant Protein Intake and Dietary Diversity Are Independently Associated with Nutrient Adequacy in French Adults. Journal of Nutrition. 2016;146(11):2351-60. doi: 10.3945/jn.116.236869. https://agroparistech.hal.science/hal-01488441.
Bianchi CM, Mariotti F, Verger EO, Huneau J-F. Pregnancy Requires Major Changes in the Quality of the Diet for Nutritional Adequacy: Simulations in the French and the United States Populations. PLoS ONE. 2016;11(3):e0149858. doi: 10.1371/journal.pone.0149858. https://agroparistech.hal.science/hal-01576902.
Bost M, Houdart S, Oberli M, Kalonji E, Huneau J-F, Margaritis I. Dietary copper and human health: Current evidence and unresolved issues. Journal of Trace Elements in Medicine and Biology. 2016;35:107 - 15. doi: 10.1016/j.jtemb.2016.02.006. https://agroparistech.hal.science/hal-01572305.
Cantalapiedra-Hijar G, Fouillet H, Huneau J-F, Fanchone A, Doreau M, Noziere P, Ortigues Marty I. Relationship between efficiency of nitrogen utilization and isotopic nitrogen fractionation in dairy cows: contribution of digestion v. metabolism? Animal. 2016;10(02):221-9. doi: 10.1017/s1751731115002025. https://hal.science/hal-01260291.
Deveaux A, Fouillet H, Petzke KJ, Hermier D, André E, Bunouf P, et al. A slow-compared with a fast-release form of oral arginine increases its utilization for nitric oxide synthesis in overweight adults with cardiometabolic risk factors in a randomized controlled study. Journal of Nutrition. 2016;146(7):1322-9. doi: 10.3945/jn.116.231910. https://hal.science/hal-01531692.
Deveaux A, Pham I, West SG, André E, Lantoine-Adam F, Bunouf P, et al. L-arginine supplementation alleviates postprandial endothelial dysfunction when baseline fasting plasma arginine concentration is low: A randomized controlled trial in healthy overweight adults with cardiometabolic risk factors. Journal of Nutrition. 2016;146(7):1330-40. doi: 10.3945/jn.115.227959. https://agroparistech.hal.science/hal-01576899.
Galmiche G, Huneau J-F, Mathe V, Mourot J, Simon N, Le Guillou C, Hermier D. n-3 Fatty acids preserve muscle mass and insulin sensitivity in a rat model of energy restriction. British Journal of Nutrition. 2016;116(7):1141-52. doi: 10.1017/s0007114516003111. https://agroparistech.hal.science/hal-01488440.
Graffouillere L, Deschasaux M, Mariotti F, Neufcourt L, Shivappa N, Hebert JR, et al. Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized control trial. The American Journal of Clinical Nutrition. 2016;103(3):878-85. doi: 10.3945/ajcn.115.126243. https://agroparistech.hal.science/hal-01576901.
Graffouillere L, Deschasaux M, Mariotti F, Neufcourt L, Shivappa N, Hebert JR, et al. The Dietary Inflammatory Index Is Associated with Prostate Cancer Risk in French Middle-Aged Adults in a Prospective Study. Journal of Nutrition. 2016;146(4):785–91. doi: 10.3945/jn.115.225623. https://agroparistech.hal.science/hal-01576903.
Hermier D, Guelzim N, Martin PGP, Huneau J-F, Mathe V, Quignard-Boulangé A, Lasserre F, Mariotti F. NO synthesis from arginine is favored by alpha-linolenic acid in mice fed a high-fat diet. Amino Acids. 2016;48(9):2157-68. doi: 10.1007/s00726-016-2243-y. https://hal.science/hal-01531702.
Mariotti F, Huneau J-F. Plant and animal protein intakes are differentially associated with large clusters of nutrient intake that may explain part of their complex relation with cvd risk. Advances in Nutrition. 2016;7(3):559-60. doi: 10.3945/an.115.011932. https://hal.science/hal-01532564.
Books and book chapters
Mariotti F, Dardevet D. The Effect of Diet and Nutrition on Postprandial Metabolism, 2020. https://hal.science/hal-03005980.
Dagnelie PC, Mariotti F. 1 - Vegetarian Diets: Definitions and Pitfalls in Interpreting Literature on Health Effects of Vegetarianism. Edtion ed. In: Mariotti F, ed. Vegetarian and Plant-Based Diets in Health and Disease Prevention: Academic Press, 2017:3 - 10. https://agroparistech.hal.science/hal-01576884.
Mariotti F. Vegetarian and Plant-Based Diets in Health and Disease Prevention: Academic Press, 2017. https://agroparistech.hal.science/hal-01727593.
Mariotti F. 36 - Plant Protein, Animal Protein, and Cardiometabolic Health. Edtion ed. In: Mariotti F, ed. Vegetarian and Plant-Based Diets in Health and Disease Prevention. (united kingdom): Academic Press, 2017:643 - 65. https://agroparistech.hal.science/hal-01576881.
Mariotti F. Preface. Edtion ed. In: Mariotti F, ed. Vegetarian and Plant-Based Diets in Health and Disease Prevention. (united kingdom): Academic Press, 2017:xxxiii - xxxiv. https://agroparistech.hal.science/hal-01576883.
Mariotti F. 35 - Plant Protein, Animal Protein, and Protein Quality. Edtion ed. In: Mariotti F, ed. Vegetarian and Plant-Based Diets in Health and Disease Prevention. (united kingdom): Academic Press, 2017:621 - 42. https://agroparistech.hal.science/hal-01576882.
Mariotti F. Protein Intake Throughout Life and Current Dietary Recommendations. Edtion ed. The Molecular Nutrition of Amino Acids and Proteins: Elsevier BV, 2016:13--25. https://agroparistech.hal.science/hal-01576885.
